Near this site in
1969, Jean-Francois Borel, a microbiologist on
vacation, collected some soil samples and took them back to his
laboratory in Basel, Switzerland, for testing. On January 31,
1982, an
organism that produced Cyclosporin A was discovered in those soil
samples. Cyclosporin A later was determined to be a product of
several
fungi including Tolypocladium inflatum, Trichoderma polysporun, and Cylindrocarpon
lucidum. Tolyplocladium inflatum is the fungus that was
found here at this site. Cyclosporin A is an
immunosuppressant drug
that can be used in organ transplantations to prevent patients from
rejecting the transplanted organ and was approved by the USDA in 1983
for organ transplantation. The drug acts by inhibiting the action
of
interleukin-2, a messenger in the immune system that attacks foreign
bodies. This drug has also been used to treat psoriasis,
rheumatoid
arthritis, other autoimmune disorders, atopic dermitis, and ulcerative
colitis. The fungus isolated from soil has saved many lives.
--L. Crane
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